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Atorvastatin is used to treat high cholesterol. Atorvastatin is also used to lower the risk of stroke, heart attack, or other heart complications in people with coronary heart disease or type 2 diabetes. Atorvastatin is a cholesterol-lowering medication that blocks the production of cholesterol (a type of fat) in the body. Atorvastatin reduces low-density lipoprotein (LDL) cholesterol and total cholesterol in the blood. Lowering your cholesterol can help prevent heart disease and hardening of the arteries, conditions that can lead to heart attack, stroke, and vascular disease.
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Atorvastatin calcium drug combination (Pravastatin 300 mg 2×/day vs. Atorvastatin 5 mg/day) increased the risk of early heart failure in postmenopausal women the placebo-controlled Veterans Affairs (VA) Heart Failure Randomized Clinical Trials (HFT) study. Women with known cardiac disease (myocardial infarction, unstable angina, or peripheral artery disease) were randomized to receive either 400mg of Pravastatin calcium (50mg plus an additional 20 mg of Pravastatin calcium) or Atorvastatin 5 mg/day (100mg of calcium). The primary outcomes were all cause mortality, cardiovascular events, and hospitalization due to myocardial infarction (hospital admission due to congestive heart failure and non-cardiovascular causes of death). The researchers also analyzed their data to determine if the drug interaction findings would change when comparing the two calcium supplements.
The researchers analyzed data from HFT participants who were randomly assigned to receive either 400mg of Pravastatin calcium or Atorvastatin 5 mg/day, stratified by age, and compared to data from those who were randomized to receive placebo. (The researchers didn't know who received which calcium supplement at baseline and who did not because Buy montelukast 10 mg online all the study participants were randomized.)
The researchers noted in their analysis (published the journal Angiology in February 2010, titled "The Effects of Pravastatin and Atorvastatin calcium on Early Heart Failure, Mortality, and Hospitalization") that they found those receiving Pravastatin calcium showed significantly higher levels of C-reactive protein than those in the placebo group. C-reactive protein is an indicator of inflammation in the body that may lead to heart disease and all of the other conditions that lead to death in older people.
Atorvastatin and Pravastatin calcium don't seem to affect levels of HDL-cholesterol, which was measured at baseline, but the level of very low densities cholesterol, known as VLDL-cholesterol, didn't change between groups. That's important because the VLDL-cholesterol levels are thought to be the strongest risk factor for cardiovascular disease.
The researchers also noted that it's not clear whether drug store 6th ave nyc or an interaction between the cardiovascular risk factors of heart failure and diabetes is at play. Other studies have found an association between diabetes and heart failure independently of risk factors. They write, though, that:
"We are unable to exclude that the higher triglyceride levels due to calcium intake or the lower cholesterol levels due to Pravastatin calcium intake is in part the cause Buy generic viagra soft tabs of higher mortality among the Pravastatin calcium users. It is important that future investigations are designed to examine the possibility of calcium to Pravastatin interaction how much does atorvastatin 20 mg cost and its potential effect on mortality among subjects with diabetes and heart failure."
So it appears that not only is the Pravastatin calcium causing higher C-reactive protein, but it's also decreasing HDL-cholesterol.
The Bottom Line
The use of Pravastatin calcium may increase your risk of early heart failure and may affect your ability to maintain low cholesterol levels, especially when you use drugs that decrease HDL-cholesterol, like statins. A few months back, New York Magazine ran an unflattering profile on Lena Dunham, the 19-year-old creator of HBO's Girls. Among the highlights was a bit about Dunham's mother, Lenny, "a voracious reader who would eat anything she'd never had before." The magazine also reported that in Dunham's first week of high school, her mother sent a note that read: "I don't know if I'm going to get it today."
Dunham responded to the characterization by writing a personal essay on her Best canadian pharmacy to buy viagra online web site, about just how much her mother inspires and the impact her love for book has had on her life. It's a deeply personal essay, and it's well worth reading.
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One major theme that emerges is Dunham's personal journey from having a difficult mother to supportive or loving one. When I was a tween, obsessed with books; I spent hours in my dorm room on MySpace reading to my fellow students and making lists of my favorite books.
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